“Therapeutic Insights From New Diabetes Gene Discoveries”

March 18 noon – March 19 noon, 2008

Rittenhouse Hotel, Philadelphia, PA

Agenda

March 18, 12:00 pm – 5:30

Keynote: “Exploring The Limits of Genetics” Peter Goodfellow, D. Phil, FRS

Session 1 New Discoveries In The Genetics Of Diabetes

Chairman Francis Collins, MD, PhD

Genetics of Type I Diabetes John Todd, PhD

Genetics of Type II Diabetes David Altshuler, MD, PhD

Genetics of Monogenic/Neonatal Diabetes Andrew Hattersley, DM

“Round Table” Chair, Francis Collins, MD, PhD, Lead Discussants, Frances Ashcroft, BA, PhD, DSc,

Ron Kahn, MD, Ken Polonsky MD with John Todd, PhD, David Altshuler, MD, PhD,

Andrew Hattersley, DM

Session 2 Successes in the Development of Therapies From Genetic Discoveries

Chairman Chris Austin, MD

Targeted Drug Development, Bench to Bedside Christopher Austin, MD

Novel Approaches to Drug Development Stuart Schreiber, PhD

Drug Discovery Based on Combining Multiple Data Sets Eric Schadt, PhD

“Awards Dinner” 6:30 pm-9:30 pm

The National Constitution Center on Independence Mall

March 19, 8:30 am – 1:00

Session 3 Breakthrough Ideas For Development Of Novel Therapeutics

Chairman Peter Goodfellow, D. Phil, FRS

A. Potential Targets/Pathways and Processes

Immunotherapy Matthias von Herrath , MD

Type I Diabetes Prevention Kevan Herold, MD

Pathways and Targets to Improve Beta-cell Mass and Function Klaus Kaestner, PhD

B. Potential Targets/Proteins

CDKN2A/2B/ARF (p15/p16) Norman Sharpless, MD

Will Human Genetics Play A Role In Diabetes Drug Discovery? Thomas Hughes, PhD

“Round Table” Chair, Peter Goodfellow, D.Phil, FRS, Lead Discussants, David Moller, MD,

Linda Wicker, PhD, Paul Strumph, MD, with Matthias von Herrath, MD, Kevan Herold, MD,

Klaus Kaestner, PhD, Norman Sharpless, MD, Thomas Hughes, PhD

 

March 2008 - The Rittenhouse Hotel

Session 1 

Hal E. Broxmeyer, Ph.D. welcomes participants to the NDRI Genetics Conference.

Peter Goodfellow, D. Phil, FRS gives the keynote speech.

Francis S. Collins, M.D., Ph.D., Co-Chairman of the NDRI conference, greets the gathered scientists.

John Todd, Ph.D., FMedSci discusses the Genetics of Type 1 Diabetes.

David Altshuler, M.D., Ph.D.  relates findings on Type 11 Diabetes.

Francis Ashcroft, Ph.D, DSc, FRS shares her knowledge.

Ron Kahn, MD and Kenneth S. Polonsky, MD provoke lively discussion.

March 2008 - The Rittenhouse Hotel

Session 2 

Christopher P. Austin, MD explores targeted drug development.

Stuart L. Schreiber, Ph.D. discusses novel approaches to drug development.